Creating a graphic memoir: Should I use upper- or lowercase lettering?

I came across an interesting debate in Scott McCloud's Making Comics: Storytelling Secrets of Comics, Manga, and Graphic Novels. I also keep going back and forth on the question of whether to use upper- or lowercase lettering in my memoir. McCloud writes (in all caps):

“On the one hand, uppercase comic book lettering has the following arguments in its favor:

About 98% of all English language comics in the last 100 years have used it, including nearly all of the comics now considered classics. If it ain't broke, why fix it?

Capital letters are easier to letter by hand.

Caps fill the space more efficiently.

Caps blend better with pictures.

Caps look better with frequent bolt/italic type.

On the other hand, advocates of using upper and lowercase letters might respond:

There are a lot of things comics have rarely done in the last 100 years, including mature themes, subtle characterization and sophisticated artwork; that's no reason not to try them.

One of the most popular comics in history, Tintin, uses upper- and lowercase lettering, as do other European comics, and it looks great.

Easier doesn't equal better.

A little white space never hurt anyone.

If upper and lowercase letters don't blend with pictures, how do we explain five centuries of illustrated books?

Bold type is over-used and melodramatic.”

My primary motivation for using uppercase lettering was to make it easier for the reader to read. However, I would like my memoir to depart from the conventional comics format of panels and balloons. I feel that lowercase lettering is something that doesn't appear in comics very frequently and I would like to embrace this alternative format. As I mentioned in my previous post, lettering by hand reveals your personality to the reader. In my opinion, this personality is even more apparent when you use lowercase letters, the way you typically write.

Here are some of my favorite comics that use both approaches:

MK Czerwiec, Taking Turns: Stories from HIV/AIDS Care Unit 371

Kristen Radtke, Imagine Wanting Only This

Or combine the two:

MariNaomi, Turning Japanese